David E C Cole Selected Research

Calcium-Sensing Receptors

2/2015	Risk of nephrolithiasis in primary hyperparathyroidism is associated with two polymorphisms of the calcium-sensing receptor gene.
9/2014	Factors associated with vertebral fracture risk in patients with primary hyperparathyroidism.
7/2014	Codon Arg15 mutations of the AP2S1 gene: common occurrence in familial hypocalciuric hypercalcemia cases negative for calcium-sensing receptor (CASR) mutations.
7/2014	Novel homozygous inactivating mutation of the calcium-sensing receptor gene (CASR) in neonatal severe hyperparathyroidism-lack of effect of cinacalcet.
1/2014	G protein-coupled receptor mutations and human genetic disease.
4/2011	Neonatal hyperparathyroidism with a heterozygous calcium-sensing receptor (CASR) R185Q mutation: clinical benefit from cinacalcet.
3/2011	Polymorphisms at the regulatory regions of the CASR gene influence stone risk in primary hyperparathyroidism.
9/2010	Kabuki syndrome and Crohn disease in a child with familial hypocalciuric hypercalcemia.
4/2010	Calcium-sensing receptor (CASR) mutations in hypercalcemic states: studies from a single endocrine clinic over three years.
1/2009	Glial cells missing-2 (GCM2) transactivates the calcium-sensing receptor gene: effect of a dominant-negative GCM2 mutant associated with autosomal dominant hypoparathyroidism.

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David E C Cole Research Topics

Disease

9	Hypercalcemia (Milk Alkali Syndrome) 07/2015 - 08/2004
8	Hyperparathyroidism 02/2022 - 03/2002
7	type 1 familial Hypocalciuric hypercalcemia 07/2015 - 03/2002
6	Hypocalcemia 07/2015 - 03/2002
6	Breast Neoplasms (Breast Cancer) 08/2011 - 10/2006
5	Primary Hyperparathyroidism 01/2017 - 01/2007
5	Neoplasm Metastasis (Metastasis) 01/2010 - 05/2006
4	Hypoparathyroidism 02/2022 - 10/2000
4	Parathyroid Neoplasms (Parathyroid Neoplasm) 02/2022 - 02/2012
4	Asthma (Bronchial Asthma) 06/2014 - 01/2006
4	Inborn Genetic Diseases (Disease, Hereditary) 01/2014 - 01/2008
4	Neural Tube Defects (Exencephaly) 02/2009 - 12/2002
3	Vitamin D Deficiency 07/2021 - 04/2005
3	Neoplasms (Cancer) 12/2018 - 05/2006
3	Nephrocalcinosis 08/2011 - 10/2000
3	Bone Resorption 01/2010 - 09/2007
3	Pain (Aches) 03/2008 - 10/2006
3	Hyperhomocysteinemia 04/2004 - 02/2003
2	Nephrolithiasis 02/2015 - 03/2011
2	Kidney Calculi (Kidney Stone) 02/2015 - 01/2007
2	Neurologic Manifestations (Neurological Manifestations) 01/2015 - 04/2006
2	Seizures (Absence Seizure) 01/2015 - 04/2006
2	Coronary Artery Disease (Coronary Atherosclerosis) 10/2014 - 01/2005
2	Idiopathic Hypogonadotropic Hypogonadism 01/2014 - 01/2008
2	Obesity 01/2014 - 01/2008
2	Hypoxia (Hypoxemia) 01/2014 - 01/2008
2	Hemorrhage 01/2014 - 01/2008
2	Hypertension (High Blood Pressure) 01/2014 - 01/2008
2	Rickets (Rachitis) 01/2012 - 04/2005
2	Secondary Hyperparathyroidism 04/2011 - 04/2005
2	Osteoporosis 09/2010 - 08/2005
2	Hypercalciuria 07/2006 - 10/2000
1	Insulin Resistance 01/2020
1	Lung Neoplasms (Lung Cancer) 01/2018
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2018
1	DiGeorge Syndrome (Syndrome, DiGeorge) 07/2015
1	Type 2 Diabetes Mellitus (MODY) 10/2014
1	Ischemic Stroke 10/2014
1	Bone Diseases (Bone Disease) 07/2014
1	Drug-Related Side Effects and Adverse Reactions 01/2014
1	Macular Degeneration (Age-Related Maculopathy) 03/2013
1	Coumarin Resistance 04/2012
1	Infantile Hypercalcemia 02/2012
1	Liver Diseases (Liver Disease) 07/2010
1	Hypersensitivity (Allergy) 01/2010
1	Osteonecrosis (Kienbock's Disease) 07/2009

Drug/Important Bio-Agent (IBA)

17	CalciumIBA 12/2018 - 03/2002
17	Calcium-Sensing ReceptorsIBA 02/2015 - 03/2002
8	Vitamin D FDA LinkGeneric 01/2017 - 04/2005
8	Diphosphonates (Bisphosphonates)IBA 05/2011 - 05/2006
6	Folic Acid (Vitamin M)FDA LinkGeneric 02/2009 - 12/2002
5	Alkaline PhosphataseIBA 01/2015 - 11/2002
4	Proteins (Proteins, Gene)FDA Link 01/2015 - 10/2000
4	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2014 - 01/2006
4	Parathyroid Hormone (Parathormone)IBA 01/2014 - 04/2005
4	GTP-Binding Proteins (G-Protein)IBA 01/2014 - 01/2008
4	Pamidronate (Aredia)FDA LinkGeneric 04/2011 - 10/2006
4	collagen type I trimeric cross-linked peptideIBA 03/2008 - 05/2006
3	Cinacalcet (Sensipar)FDA Link 07/2015 - 04/2011
3	Rhodopsin (Visual Purple)IBA 01/2014 - 01/2008
3	Pharmaceutical PreparationsIBA 01/2014 - 01/2008
3	HomocysteineIBA 04/2004 - 01/2003
2	Transcription Factors (Transcription Factor)IBA 02/2022 - 11/2002
2	DNA (Deoxyribonucleic Acid)IBA 02/2022 - 01/2008
2	Cholecalciferol (Vitamin D3)FDA Link 07/2021 - 01/2010
2	Insulin (Novolin)FDA Link 01/2020 - 10/2014
2	25-hydroxyvitamin DIBA 01/2017 - 06/2014
2	Calcitriol (Calcijex)FDA LinkGeneric 07/2014 - 07/2006
2	Luteinizing Hormone (Lutropin)FDA LinkGeneric 01/2014 - 01/2008
2	G-Protein-Coupled Receptor KinasesIBA 01/2014 - 01/2008
2	MelanocortinsIBA 01/2014 - 01/2008
2	Endothelins (Endothelin)IBA 01/2014 - 01/2008
2	Melanocortin Receptors (Melanocortin Receptor)IBA 01/2014 - 01/2008
2	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2014 - 01/2008
2	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2014 - 01/2008
2	Vasopressins (Vasopressin)IBA 01/2014 - 01/2008
2	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2014 - 01/2008
2	Follicle Stimulating Hormone (Follitropin)FDA Link 01/2014 - 01/2008
2	Clodronic Acid (Clodronate)IBA 03/2008 - 10/2006
2	Biomarkers (Surrogate Marker)IBA 09/2007 - 05/2006
1	N 30IBA 01/2018
1	Polysaccharides (Glycans)IBA 01/2018
1	A 7 (A-7)IBA 11/2017
1	RNA (Ribonucleic Acid)IBA 07/2017
1	Glucose (Dextrose)FDA LinkGeneric 10/2014
1	Codon (Codons)IBA 07/2014
1	Vitamin D-Binding ProteinIBA 06/2014
1	NeuropeptidesIBA 01/2014
1	LigandsIBA 01/2014
1	Complement Factor H (Factor H)IBA 03/2013
1	Cytochrome P-450 CYP2C9IBA 04/2012
1	AnticoagulantsIBA 04/2012
1	CateninsIBA 02/2012
1	Vitamin D3 24-HydroxylaseIBA 02/2012
1	Furosemide (Lasix)FDA LinkGeneric 04/2011
1	Dihydrotachysterol (AT 10)IBA 04/2011

Therapy/Procedure

10	Therapeutics 01/2014 - 05/2006
3	Parathyroidectomy 05/2011 - 11/2007
3	Heart Transplantation (Grafting, Heart) 09/2005 - 10/2003
1	Thymectomy 05/2011